Therapeutic Targets and Rational Drug Designing for Antitubercular Drugs

  • Mohammad ASif


Complication in structural and chemical composition of the mycobacterial cell wall causes difficulties in the treatment of tuberculosis. Due to structural complication, mycobacterium makes many antibiotics ineffective and prevents the entry of drugs in to mycobacterial cells. Tuberculosis is still the second most imperative infectious disease worldwide due to the most important reason for this is drug resistant tuberculosis, persistent infection and synergism of tuberculosis with HIV. In present review we discussed brief introduction of tuberculosis followed by the application of currently used drug and their targets significant action against tuberculosis for the development and drug designing