Nano-Cosmeceuticals: An emerging Novel trend towards Dermal care

  • Karuna Kumari Department of Pharmacy, School Of Medical and Allied Sciences, Galgotias University, Uttar Pradesh, India
Keywords: Cosmeceuticals, nanotechnology, nano-carriers, Dermal products

Abstract

Abstract: In today’s world consumers are looking for personal care products that supply multiple benefits with minimal efforts. They also expect the latest technology advances to be incorporated into innovative formulations. The trend toward therapeutic cosmetics will lead to a better understanding of modern ingredients and their assessment techniques. In this review, we highlighted the most important scientific articles, expert opinions by regulatory authorities, and patent literature from Europe and the USA for the time period between 2000 and 2010 concerning the use of nanotechnology in dermatological, dental, and hair-care products intended for improving the appearance of the user. We briefly discussed public opinion of nanotechnology in general, and include the most important definitions related to this emerging technology along with a summary of the general characteristics of nanoparticles and their safety aspects. In recent times, application of nanotechnology is rising in the arena of cosmeceuticals and seems to be promising in overcoming certain drawbacks associated with the traditional products. The nanotechnology-based delivery techniques have proved to offer advantages of greater stability, higher efficacy and have also been reported to show prolonged effects. 

Author Biography

Karuna Kumari, Department of Pharmacy, School Of Medical and Allied Sciences, Galgotias University, Uttar Pradesh, India
Assistant Professor

References

1. Maynard AD. Nanotechnology: a research strategy for addressing risk. Project on Emerging Nanotechnologies. Woodrow Wilson International Centre for Scholars; 2006.
2. Oberdoester G, Oberdoester E, Oberdoester J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect.2005; 113(7):823–839.
3. U.S. Food and Drug Administration. Is it a cosmetic, a drug, or both? (Or is it soap?). Available from: http://www.fda.gov/cosmetics/guidancecomplianceregulatoryinformation/ucm074201.htm. [Last accessed on 01 Aug 2015].
4. B. S. Oricha, Cosmeceuticals: A review, Afr. J. Pharm. Pharmacol., 4(4), 127–129 (2010).
5. Fulekar MH. Nanotechnology: importance and application. India: IK International Publishing House; 2010.
6. Brandt FS, Cazzaniga A, Hann M. Cosmeceuticals: current trends and market analysis. Semin Cutaneous Med Surg 2011;30:141–3.
7. Padamwar MN, Pokharkar VB. Development of vitamin loaded topical liposomal formulation using factorial design approach: drug deposition and stability. Int J Pharm 2006;320:37–44.
8. Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW et al. Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nano. 2009; 4:747–51.
9. Nand K. Proniosome Gel: Potential Carrier System in Topical/Transdermal Delivery for Drugs and Cosmetics/Cosmeceuticals. Pharmainfo.net. 2010; 16:35.
10. U.S. Food and Drug Administration, Nanotechnology Task Force Report. July 2007. http://www/fda.gov/nanotechnology/taskforce/ report2007.html.
11. Petersen R. Nanocrystals for use in topical cosmetic formulations and method of production thereof. Abbott GmbH & Co. US Patent 60/866233 (2008).
12. L’Oréal. Use of hyperbranched polymers and dendrimers comprising a particular group as film-forming agent, filmforming compositions comprising same and use particularly in cosmetics and pharmaceutics. US Patent 6432423, (2002).
13. Dureja H, Kaushik D, Gupta M, Kumar K, Lather V. Cosmeceuticals: An Emerging Concept. Indian J Pharmacology. 2005; 37(3):155-159.
14. Muller-Goymann CC. Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration. Eur J Pharm Biopharm 2004;58:343–56.
15. M. Mezei and V. Gulasekharam, Liposomes—A selective drug delivery system for the topical route of administration. I. Lotion dosage form., Life Sciences, 26, 1473–1477 (1980).
16. Uchegbua IF, Vyas SP. Non-Ionic Surfactant Based Vesicles (Niosomes) in Drug Delivery. Int J Pharm.1998; 172: 33-70.
17. http://www.dior.com/beauty/int/en/skincare/faceskincare/fi rst_wrinkle_correction/r6080/y0626502/ py0626502.html
18. http://www.urbansense.com.au/main/page_products_botanical_skincare.html
19. http://www.karavita.com/products/29/Clearly-It-Complexion-Mist.aspx
20. http://www.karavita.com/products/29/Clearly-It-Complexion-Mist.aspx
21. M. Rosenblat, N. Volkova, R. Coleman, and M. Aviram, Antioxidant and anti-atherogenic properties of liposomal glutathione: Studies in vitro, and in the atherosclerotic apolipoprotein E-deficient mice. Atherosclerosis 195, 61 (2007).
22. R. Gottil, V. Andrisanol, V. Cavrini, and A. Bongini, Determination of glutathione in pharmaceuticals and cosmetics by HPLC with UV and fluorescence detection. Chromatographia 39, 23 (1994).
23. L’Oreal, US Patent 4830857, 1989.
24. L’Oréal, French Patent 2315991, 1975.
25. Kazi KM. Niosome: a future of targeted drug delivery systems. J Adv Pharm Technol Res 2010;1:374–80.
26. Ball P. Nanotechnology in the firing line. 2003. URLhttp://nanotechweb.org/cws/article/indepht/18804
27. Maibach HI, Choi MJ. Liposomes and niosomes as topical drug delivery systems. Skin Pharmacol Physiol 2005;18:209-19
28. Vyas J, Vyas P, Raval D, et al. Development of topical niosomal gel of benzoyl peroxide. ISRN Nanotechnol 2011;1-6. DOI: 10.5402/2011/503158
29. Kempf M, Theobald U, Fiedler HP. Economic improvement of the fermentative production of Gallidermin by Staphylococcus gallinarum. Biotechnol Lett 1999;21(8):663-7
30. Manosroi A, Khanrin P, Lohcharoenkal W, et al. Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes. Int J Pharm 2010;392(1):304-10
31. P. Boonme, Applications of microemulsions in cosmetics. J. Cosmet. Dermatol. 6, 223 (2007).
32. V. B. Junyaprasert, P. Boonme, S. Songkro, K. Krauel, and T. Rades, Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions. J. Pharm. Pharmaceut. Sci. 10, 288 (2007).
33. V. B. Junyaprasert, P. Boonme, D. E. Wurster, and T. Rades, Aerosol OT microemulsions as carriers for transdermal delivery of hydrophobic and hydrophilic local anesthetics. Drug Del. 15, 323 (2008).
34. Petersen R. Nanocrystals for use in topical cosmetic formulations and method of production thereof. Abbott GmbH and Co. US Patent 60/866233; 2008.
35. Anna Coll Perdiguer, Francisco Javier Galan Dachs, Nuria Carreras, Valdivia, Nanoemulsion of the oil water type, useful as an ophthalmic vehicle and process for the preparation thereof Assignee: Laboratorios Cusi, S.A. (Barcelona, ES) 1997.
36. Banker GS, Lieberman HA, Rieger MM: Pharmaceutical dosage forms. Disperse systems, Marcel Dekker, Edition 2, Vol. 3, 2002: 339-40,343-44.
37. Quintero Lirio, Mckellar John Alexander, Clark David E: Nanoemulsion Assignee: Baker Hughes Incorporated (Houston, TX, US) 2010.
38. Bouchemal K, Briancon S, Fessi H, Perrier E: Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimization .International Journal of Pharmaceutics 2004;280:243.
39. Montserrat, Roca Foguet, (Leverkusen DE) Nanoemulsion. United States Patent Application 20090324727 Assignee: Biofrontera Bioscience Gmbh (Leverkusen, De).
40. Erol Yilmaz, Hans-Hubert Borchert: Design of a phytosphingosine-containing, positively-charged nano- emulsion as a colloidal carrier system for dermal application of ceramides. European Journal of Pharmaceutics and Biopharmaceutics 2005; 60:93.
41. http://www.korres.com/default.aspx
42. Simonnet et al.: Nanoemulsion based on ethoxylated fatty ethers or on ethoxylated fatty esters and its uses in the cosmetics, dermatological and/or ophthalmological fields 2002.
43. Bansal S, Bansal M, Kumria R. Nanocrystals: current strategies and trends. Int J Res Pharm Biomed Sci 2012;3:406-19.
44. Drug-Dev Newsletter. Dendrimers and dendrons: facets of pharmaceutical nanotechnology. Available from: http://www.kellerfoundation.com/ME2/dirmod.asp?sid=4306B1E9C3CC4E07A4D64E23FBDB232C&nm=Back+Issues&type=Publishing&mod=Publications%3A%3AArticle&mid=8F3A7027421841978F18BE895F87F791&tier=4&id=9B9BA1DAA5BE455A85A81D97382FE885. [Last accessed on 05 Aug 2015]
45. J. Sakamoto, A. Annapragada, P. Decuzzi, and M. Ferrari, “Antibiological barrier nanovector technology for cancer applications,” Expert Opinion on Drug Delivery, vol. 4, no. 4, pp. 359– 369, 2007.
46. Kothamasu P, Kanumur H, Ravur N. Nanocapsules: the weapons for novel drug delivery systems. BioImpacts 2012;2:71–81.
47. Lademann J, Weigmann HJ, Rickmeier CH, et al. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol Appl Skin Physiol. 1999; 2:247–256.
48. Butz T. Dermal penetration of nanoparticles: what we know and what we don’t. Cosmetic. Science Conference Proceedings, Munich. SÖFW Journal. 2009; 135(4):8–10.
49. Puri D, Bhandari A, Sharma P, Choudhary D. Lipid Nanoparticles (Sln, Nlc): A Novel Approach For Cosmetic And Dermal Pharmaceutical. Journal of Global Pharma Technology. 2010; 2(5):1-15.
50. H. Furukawa and T. Limura, “Copolymer having carbosiloxane dendrimer structure, and composition and cosmetic containing the same,” U.S. Patent 20120263662A1, October 2012.
51. S.Hyde, A. Andersson, K. Larsson et al., The Language of Shape, Elsevier, New York, NY, USA, 1st edition, 1997.
52. S. C. Kimmes and C. Feltin, “Cosmetic composition comprising an oil and a polymer both bearing a hydrogen-bond-generating joining group, and cosmetic treatment process,” European Patent 2575751A1, April 2013.
53. J. T. Simonnet, O. Sonneville, and S. Legret, “Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological, pharmaceutical, and/or ophthalmological fields,” U.S. Patent 6274150 B1, August 2001.
54. Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P. Human skin penetration of sunscreen nanoparticles: In vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol. 2007; 20:148–154.
55. Haveli SD, Walter P. Hair fibre as a nanoreactor in controlled synthesis of fluorescent gold nanoparticles. Nano Lett 2012;12:6212–7.
56. Hyde S, Andersson A, Larsson K. The Language of Shape. 1sted. New York: Elsevier; 1997.
57. “First synthesis of gold nanoparticles inside human hair for dyeing and much more,” http://www.nanowerk.com/news2/ newsid=28260.php.
58. Pluecker F, Wendel V, Hohenberg H, et al. The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronized titanium dioxide. Skin Pharmacol Appl Skin Physiol. 2001;14(Suppl 1):92–97.
59. Schulz J, Hohenberg F, Pluecker F, et al. Distribution of sunscreens on skin. Adv Drug Deliv Rev. 2002; 54(Suppl1):S157–S163.
60. Muzzarelli RAA, Mattioli-Belmonte M, Pugnaloni A, et al. Biochemistry, histology and clinical uses of chitins and chitosans in wound healing.
61. In: Jollés P, Muzzarelli RAA, editors. Chitin and Chitinases. Basel, Swizterland: Birkhaüser Verlag; 1999. pp. 251–264.
62. Muzzarelli RAA, Muzzarelli C. Chitin nanofibrils. In: Dutta PK, editor. Chitin and Chitosan: Research Opportunities and Challenges. Contai, India: SSM International Publication; 2005. pp. 129–146.
63. Morganti P, Fabrizi G, Bruno C. Protective effects of oral antioxadants on skin and eye function. Skinmed. 2004; 3(6):310–316.
64. J.Pardeike, A.Hommoss, andR.H.M¨uller, “Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products,” International Journal of Pharmaceutics, vol. 366, no. 1-2,pp. 170– 184, 2009.
65. V. Jenning, A. Gysler, et al, Vitamin A loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting to the upper skin, Eur. J. Pharamaceut. Biopharmaceut., 49, 211–218 (2000).
66. S. A. wissing and R. H. Müller, Solid lipid nanoparticles (SLN) as a novel carrier c xc x offering prolonged release of perfume Allure (Chanel), Int., Symp. Control. Release Bioact. Mater. 27, 311–312 (2000).
67. http://www.lorealparis.com.au/skincare/face-care/revitalift/day-cream.aspx
68. http://www.avg-personalcare.it/Uploads/PPT_Lipobelle_Gold.pdf
69. http://www.chanel.com/en_AU/fragrance-beauty/Fragrance-Coco-Mademoiselle-COCOMADEMOISELLE-EMULSION-HYDRATANTE-119835
70. EP2583665A4, US8980293, US20130095157, WO2011162478A2, WO2011162478A3, Cosmetic composition containing retinol stabilized by porous polymer beads and nanoemulsion , EP 2583665 A2, 2013.
71. Macrene Alexiades-Armenakas, Multi-active microtargeted anti-aging skin cream polymer technology ,
EP 2579834 A4, 2015.
72. Silvia Nair Goyanes, Mirta Ines Aranguren, Nancy Lis Garcia, Lucia Mercedes Fama, Laura Ribba, Alain Dufresne, Biodegradable, biocompatible and non-toxic material, sheets consisting of said material and the use thereof in food, pharmaceutical, cosmetic and cleaning products
, US 20130034638 A1, 2013.
73. Bernd Sachweh, Wieland Koban, Wendell Wohlleben, Wolfgang Peukert, Robin Klupp Taylor, Monica Distaso, Metal Oxide Nanocomposites for UV Protection, US 20130022655 A1,2013.
74. Tomiko Takakura, Oil-in-water type emulsion sunscreen cosmetic composition ,US 20130011348 A1, 2013.
75. Rebeccah Brown, Thomas J. Koob, Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods ,US 20130018415 A1, 2013.
76. John Jennings, Dietmar Hüglin, Jianwen Mao, Andreas MÜHLEBACH, Preparation of cationic nanoparticles and personal care compositions comprising said nanoparticles ,EP 2254545 A2, 2010.
77. Prithwiraj Maitra, Steven E. Brown, John R. Glynn, Jr., Jason Rothouse, John C. Brahms, Michael J. Fair, Gel Technology Suitable for Use in Cosmetic Compositions ,US 20100266649 A1, 2010.
78. T. G. Smijs and S. Pavel, “Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness,” Nanotechnology, Science and Applications, vol. 4, no. 1, pp.95–112, 2011.


79. L’Oreal Paris, http://www.lorealparisusa.com/en/Products/ SkinCare/Moisturizers/RevitaLift-Anti-Wrinkle-Firming-Day-Cream-SPF-18.aspx.
80. D. Ereno, “Well-grounded Beauty,” http://revistapesquisa .fapesp.br/en/2008/04/01/wellgrounded-beauty/.
81. M. D. Carmen, V. Pereda, A. Polezel et al., “Sericin cationic nanoparticles for application in products for hair and dyed hair,” U.S. Patent 20120164196, June 2012.
82. K. Ertel, “Personal cleansing products: properties and use,” in Cosmetic Formulation of Skin Care Products, Z. D. Draelos and L. A. Thaman, Eds., pp. 32–36, Taylor & Francis, New York, NY, USA, 2006.
83. “Nanocyclic cleanser pink,”http://www.nanocyclic.com/ProductDetails. asp?ProductCode=CY-40P.
84. Lautenschlӓger H. Liposomes, Handbook of cosmetic science and technology, 2006, pp155-163
85. Chourasia, MK, Kang L, Chan SY. Nanosized ethosomes bearing ketoprofen for improved transdermal delivery. Pharmaceutical Sciences, 2011, 1(1): 60- 67.
86. Dubey V, Mishra D, Dutta T, Nahar M, Saraf DK, Jain NK. Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes. Journal of Controlled Release, 2007, 123(2): 148-154.
87. Barry BW, Williams AC. Permeation enhancement through skin, In:Swarbrick, J., Boylan, J. C. (Eds). Encyclopedia of Pharmaceutical Technology, 11, Marcel Dekker, New York, 449 - 493.
88. Mezei M, Gulasekharam V. Liposomes: a selective drug delivery system for the topical route of administration: gel dosage form. Journal of Pharmacy and Pharmacology, 1982, 34(7): 473-474.
89. T.H.Ha, J. Y. Jeong, B. T. Y. H. Jung, and J. K. Kim, “Cosmetic pigment composition containing gold or silver nano-particles,” European Patent 1909745A1, April 2008.
90. P. J. L. Viladot, G. R. Delgado, and B. A. Fernandez, “Lipid nanoparticle capsules.,” European Patent 2549977A2, January 2013.
91. S.W. Amato, A. Farer,W. M. Hoyte, M. Pavlovsky et al., “Coatings formammalian nails that include nanosized particles,” U.S. Patent 2007/002207, August 2007.
92. NanoLabs, http://nanolabs.us/press-releases/green-chemistryand- new-thinking-at-playas-nano-labs-ctle-receives-provisional-patent-for-unique-nanotech-nail-polish/.
93. Yah CS, Simate G, Iyuke SE. Nanoparticles toxicity and their routes of exposures. Pak J Pharm Sci 2012;25:477–91.
94. Kreyling WG, Semmler-Behnke M, Moller W. Ultrafine particle-lung interactions: does size matter? J Aerosol Med 2006;19:74-83.
95. Zhu MT, Feng WY, Wang Y, Wang B, Wang M, Ouyang H, et al. Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment. Toxicol Sci 2009;107:342-51.
96. Wang B, Feng WY, Wang M, Wang TC, Gu YQ, Zhu MT. Acute toxicological impact of nano-and submicro-scaled zinc oxide powder on healthy adult mice. J Nanopart Res 2008;10:263-76.
97. Paul JAB, Roel PFS. Toxicological characterization of engineered nanoparticles. In: Gupta RB, Kompella UB. editors. Nanoparticle technology for Drug Delivery. New York: Taylor and Francis; 2006. p. 161–70.
98. Raj S, Jose U, Sumod S, Sabitha M. Nanotechnology in cosmetics: opportunities and challenges. J Pharm BioAllied Sci 2012;4:186–93.
99. Buzea C, Pacheco II, Robble K. Nanomaterial and nanoparticles: sources and toxicity. Biointerphases 2007;2:MR17-71.
100. Toll R, Jacobi U, Richter H, Lademann J, Schaefer H, Blume-Peytavi U. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J Invest Dermatol 2004; 123:168–76.
Published
2017-03-03
Section
Reviews